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KMID : 0380020050200030177
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Korean Journal of Biotechnology and Bioengineering
2005 Volume.20 No. 3 p.177 ~ p.182
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CSP (Chiral Stationary Phase) for SMB Chromatography
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Kim Byung-Lip
Kim In-Ho
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Abstract
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Simulated moving bed (SMB) chromatography was used in the petrochemical industry in the 1960s and its use has been widened to separate chiral compounds in the 1990s. Chiral stationary phase (CSP) is the key component in SMB for the separation of the chiral compounds. CSP has been developed for the analytical use in HPLC, however, its development successfully adapted for the preparative use in SMB chromatography. This review covers the present state-art technology of CSP for SMB chromatography in terms of selectivity, stability, and capacity.
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KEYWORD
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SMB, CSP, chiral compounds, selectivity, stability, capacity
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